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UCLA researchers say genetic mutation could be key to treating fatal brain tumors

Published Wed, 05 Mar 2025 18:29:41 GMT

Researchers at UCLA say they may have made a breakthrough in the battle against one of the hardest-to-treat forms of cancer.Glioblastomas are terminal brain tumors with little treatment options and poor timelines for those unlucky enough to be diagnosed with them.Researchers at UCLA say they've identified a genetic alteration that occurs in 60% of those diagnosed with glioblastoma, and that genetic abnormality could be crucial in developing new effective treatments against the stubborn and aggressive cancer."The mutation causes changes in the way lipids are distributed in cancer cells, which in turn makes the cancer cells vulnerable to being destroyed," UCLA officials said in a release. The discovery could lead to a pathway to developing new treatment options.David Nathanson was one of the senior authors on the study. He's an associate professor of molecular and medical pharmacology at the David Geffen School of Medicine at UCLA and a member of the Jonsson Cancer Center. He says eve...

First fully-themed Pixar hotel in U.S. to open at Disneyland Resort later this year

Published Wed, 05 Mar 2025 18:29:41 GMT

Disney’s Paradise Pier Hotel is currently transforming into the Pixar Place Hotel, the first fully Pixar-themed hotel in the United States, Disneyland officials announced Thursday.The hotel, located at the Disneyland Resort, is expected to open this winter. Officials shared new details about the amenities, hotel-exclusive water play area and restaurant coming to the re-imagined hotel. Disneyland pitches theme park expansion plans to Anaheim neighbors The hotel will still be open during its transformation and guests can still enjoy hotel benefits such as early park entry, according to the Disney Parks blog.Beginning this summer, overnight guests will have access to the new “Finding Nemo”-inspired water play area. The area will include a 186-foot-long waterslide, a splash pad and more.In summer 2023, a "Finding Nemo"-themed splash pad will be a part of the new Pixar Place Hotel when Disney's Paradise Pier Hotel is reimagined at the Disneyland Resort. The hotel will weave the artistr...

Maven Genetics One of LA’s Top Dogs at Emerald Cup

Published Wed, 05 Mar 2025 18:29:41 GMT

L.A.’s Maven Genetics became one of the state’s premier cannabis companies two weekends ago at The Emerald Cup with a top-five finish for French Laundry. While Maven’s rise around the state in recent years has been quick, this is the biggest accolade yet for the longtime OG cultivators (Kush and metaphorically) that transitioned to the recreational side of things at the dawn of the legal era. Even before the big win, the company found itself in roughly 400 shops at any given time.XXX, Maven’s favorite OG these days.We sat down with Maven’s cofounder and president Mike Corvington to talk about the win and their experiences transitioning to a fully vertically integrated company locally that still grows in some of its legacy gardens, distributes its own product and sells its cannabis through two storefronts on top of its hundreds-long client list. “Los Angeles is a beast man,” Corvington told L.A. Weekly. “From the regulatory compliance things to L.A. in general, it’s good ...

DeSantis event underscores Twitter’s rightward shift under Musk

Published Wed, 05 Mar 2025 18:29:41 GMT

By Ali Swenson | Associated PressNEW YORK — Two years ago, signing a bill intended to punish Twitter and other major social media companies, Florida Gov. Ron DeSantis blasted the platforms as “suppressing ideas” during the COVID-19 pandemic and silencing conservative voices.What a turnaround.The new Elon Musk-owned version of Twitter helped DeSantis launch his bid for the Republican presidential nomination Wednesday. Though it was marred by technical glitches and skewered by the candidate’s critics, the forum nevertheless underscored Twitter’s unmistakable shift to the right under Musk, who bought it for $44 billion and took over in October.“The truth was censored repeatedly, and now that Twitter is in the hands of a free speech advocate, that would not be able to happen again on this Twitter platform,” DeSantis said during the Twitter Spaces event.Musk, co-hosting the event, responded to the praise by saying, “Twitter was indeed expensive, ...

How major US stock indexes fared Thursday 5/25/2023

Published Wed, 05 Mar 2025 18:29:41 GMT

Wall Street’s building mania around artificial intelligence helped lift the market, even as worries worsen about political rancor in Washington. The S&P 500 rose 0.9% Thursday after chipmaker Nvidia gave a monster forecast for upcoming sales as it benefits from the rush into AI. Because of its immense size, Nvidia is one of the most influential stocks on the market, and it helped push the Nasdaq up 1.7%. The Dow Jones Industrial Average slipped 0.1%, and the majority of stocks fell. Treasury yields rallied after reports suggested the U.S. economy is in better shape than feared. On Thursday:The S&P 500 rose 36.04 points, or 0.9%, to 4,151.28.The Dow Jones Industrial Average fell 35.27 points, or 0.1%, to 32,764.65.The Nasdaq composite rose 213.93 points, or 1.7% to 12,698.09.The Russell 2000 index of smaller companies fell 12.40 points, or 0.7%, to 1,754.60.For the week:The S&P 500 is down 40.70 points, or 1%.The Dow is down 661.98 points, or 2%.The Nasdaq is up 40.20 poi...

Marvell: Fiscal Q1 Earnings Snapshot

Published Wed, 05 Mar 2025 18:29:41 GMT

WILMINGTON, Del. (AP) — WILMINGTON, Del. (AP) — Marvell Technology, Inc. (MRVL) on Thursday reported a loss of $168.9 million in its fiscal first quarter.On a per-share basis, the Wilmington, Delaware-based company said it had a loss of 20 cents. Earnings, adjusted for one-time gains and costs, came to 31 cents per share.The results topped Wall Street expectations. The average estimate of 13 analysts surveyed by Zacks Investment Research was for earnings of 29 cents per share.The chipmaker posted revenue of $1.32 billion in the period, also surpassing Street forecasts. Eleven analysts surveyed by Zacks expected $1.3 billion.For the current quarter ending in July, Marvell expects its per-share earnings to range from 27 cents to 37 cents._____This story was generated by Automated Insights (http://automatedinsights.com/ap) using data from Zacks Investment Research. Access a Zacks stock report on MRVL at https://www.zacks.com/ap/MRVLSource

Nvidia, Ralph Lauren rise; Dollar Tree, American Eagle fall

Published Wed, 05 Mar 2025 18:29:41 GMT

NEW YORK (AP) — Stocks that traded heavily or had substantial price changes Thursday: Nvidia Corp., up $74.42 to $379.80.The maker of graphics chips for gaming and artificial intelligence reported strong first-quarter financial results.Desktop Metal Inc., down 3 cents to $1.72.Stratasys is buying the 3D printing technology company.Ralph Lauren Corp., up $5.78 to $114.The upscale clothing company beat Wall Street’s fiscal fourth-quarter earnings forecasts.Splunk Inc., down 99 cents to $95.70.The software company slipped in volatile trading, despite reporting strong first-quarter financial results.Best Buy Co., up $2.13 to $71.28.The consumer electronics retailer’s first-quarter profit beat analysts’ forecasts.Dollar Tree Inc., down $18.69 to $136.66.The discount retailer cut its profit forecast for the year.American Eagle Outfitters Inc., down $1.44 to $10.63.The clothing retailer gave investors a disappointing financial update.Digital Turbine Inc., down $6.20 to $8.23.The mobi...

2 North Carolina state legislators lose leadership roles following remarks

Published Wed, 05 Mar 2025 18:29:41 GMT

RALEIGH, N.C. (AP) — Two North Carolina state House Republicans have lost their caucus leadership positions following recent comments directed at Democratic colleagues questioning their educational attainment and religion.Reps. Keith Kidwell and Jeff McNeely have resigned as deputy majority whips after the GOP leadership team asked them to step down, House Majority Leader John Bell said. “As elected officials, we must serve by example and be accountable for our actions, especially as leaders in the caucus,” Bell said in a separate news release that didn’t specifically identify the misbehavior. “While apologies have been made and accepted, we believe this is an appropriate action and step forward.”Neither McNeely nor Kidwell, both of whom are white, responded immediately Thursday to phone messages left at their legislative offices seeking comment. They remain sitting legislators. Deputy whips are tasked with helping corral votes on issues important to members of their party. Th...

Domo: Fiscal Q1 Earnings Snapshot

Published Wed, 05 Mar 2025 18:29:41 GMT

AMERICAN FORK, Utah (AP) — AMERICAN FORK, Utah (AP) — Domo, Inc. (DOMO) on Thursday reported a loss of $24.4 million in its fiscal first quarter.The American Fork, Utah-based company said it had a loss of 69 cents per share. Losses, adjusted for stock option expense and non-recurring costs, were 17 cents per share.The company posted revenue of $79.5 million in the period.For the current quarter ending in July, Domo expects its results to range from a loss of 11 cents per share to a loss of 7 cents per share.The company said it expects revenue in the range of $78.5 million to $79.5 million for the fiscal second quarter.Domo expects full-year results to range from a loss of 39 cents per share to a loss of 27 cents per share, with revenue ranging from $323 million to $330 million._____This story was generated by Automated Insights (http://automatedinsights.com/ap) using data from Zacks Investment Research. Access a Zacks stock report on DOMO at https://www.zacks.com/ap/DOMOSource

Workday: Fiscal Q1 Earnings Snapshot

Published Wed, 05 Mar 2025 18:29:41 GMT

PLEASANTON, Calif. (AP) — PLEASANTON, Calif. (AP) — Workday Inc. (WDAY) on Thursday reported break-even earnings in its fiscal first quarter.The Pleasanton, California-based company said it had profit that was less than 1 cent on a per-share basis. Earnings, adjusted for stock option expense and non-recurring costs, were $1.31 per share.The results beat Wall Street expectations. The average estimate of 23 analysts surveyed by Zacks Investment Research was for earnings of $1.11 per share.The maker of human resources software posted revenue of $1.68 billion in the period, also surpassing Street forecasts. Twenty-five analysts surveyed by Zacks expected $1.67 billion._____This story was generated by Automated Insights (http://automatedinsights.com/ap) using data from Zacks Investment Research. Access a Zacks stock report on WDAY at https://www.zacks.com/ap/WDAYSource